Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

Figure 1

SCFAs ameliorated hyperglycemia and insulin resistance of experimental T2D. Mice were subjected to a high-fat diet (HFD) for 8 weeks, intraperitoneally (i.p.) injected with STZ, and then treated with three main SCFAs, acetate (Ac), propionate (Pr), and butyrate (But), for 12 weeks. Body weight (BW) (a) and random blood glucose (RBG) (b) were measured every 2 weeks; fasting blood glucose (FBG) (c), total cholesterol (TC) (d), total glyceride (TG) (e), low-density lipoprotein-cholesterol (LDL-C) (f), fasting insulin (FINS) (g), and homeostatic model assessment of insulin resistance (HOMA-IR) (h) values were measured at the 20th week of the experiment before sacrifice. compared with the NC group; ^# compared with the T2D group; ^& compared with the Ac or Pr group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)