What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Figure 1

A schematic of physical activity on Parkinson’s disease. Risk factors for Parkinson’s disease include dairy intake, prolonged exposure to pesticides, traumatic brain injury, and obesity. The protective factors on Parkinson’s disease include alcohol intake, tobacco smoking, coffee, black tea, and physical activity. Common forms of physical activity that benefit Parkinson’s disease include running, dancing, traditional Chinese martial arts, yoga, and weight training. Physical exercise can reduce α-Syn protein aggregation, alleviate neuronal death, regulate inflammation and oxidative stress, promote BDNF activity, modulate neuronal autophagy, and enhance mitochondrial function. Physical activity can improve motor capacity including strength, balance, and flexibility and also enhance the nonmotor symptoms, alleviate cognitive impairment, and improve depression.