Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds

Figure 2

Results of the risk of bias for all studies included in the systematic review. The items in the SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) Risk of Bias assessment (Q1–Q10) were scored with “yes” indicating low risk of bias, “no” indicating high risk of bias, or “unclear” indicating an unclear risk of bias. Q1–Q3 consider selection bias, Q4–Q5 consider performance bias, Q6–Q7 consider detection bias, Q8 considers attrition bias, Q9 considers reporting bias, and Q10 considers other biases. Q: Question. Q1: Was the allocation sequence adequately generated and applied?; Q2: Were the groups similar at baseline or were they adjusted for confounders in the analysis?; Q3: Was the allocation adequately concealed?; Q4: Were the animals randomly housed during the experiment?; Q5: Were the caregivers and/or investigators blinded from knowledge which intervention each animal received during the experiment?; Q6: Were animals selected at random for outcome assessment?; Q7: Was the outcome assessor blinded?; Q8: Were incomplete outcome data adequately addressed?; Q9: Are reports of the study free of selective outcome reporting?; and Q10: Was the study apparently free of other problems that could result in high risk of bias?