Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 1 / Review Article
Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds Table 1 Main outcome in the treatment of skin wounds using peptides of animal origin.
Intervention Main outcome Normal Infected Diabetic Ischemic Radiation + RF P R A C RWS DA RWS (%) DA RWS (%) DA RWS (%) DA RWS (%) DA [20 ] Thymosin β 4 Topic Twice 5 μ g/50μ l 62% 7 ? ? ? ? ? ? ? ? I.p. Every two days 60 μ g/300μ l 61% [21 ] TP508 Topic Single 0.03 μ g 47% 7 ? ? ? ? ? ? ? ? 0.1 μ g 39% 10 0.3 % g 79% 7 0.4 μ g 37% 10 1 μ g 43% 10 1 μ g 78% 7 3 μ g 22% 7 5 μ g ? ? [22 ] TP508 Topic Single 0.1 μ g ? ? ? ? ? ? 53% 14 ? ? [23 ] HB-107 Topic Three times 100 μ g/ml 63% 11 ? ? ? ? ? ? ? ? [15 ] Marine collagen peptides (MCP) Oral Once daily 2 g/kg 76% 16 ? ? ? ? ? ? ? ? [24 ] LL37 Topic Twice daily 10 μ g ? ? ? ? ? ? ? ? ? ? [25 ] AH90 Topic Twice daily 250 μ g/ml 64% 10 ? ? ? ? ? ? ? ? [26 ] Pardaxin (GE33) Topic ? 8 mg/ml 58% 21 85% 17 ? ? ? ? ? ? [27 ] Tylotoin Topic Twice daily 20 μ g/ml 89% 10 ? ? ? ? ? ? ? ? [28 ] CW49 Topic Twice daily 200 μ g/ml 64% 8 ? ? 23% 8 ? ? ? ? [29 ] E1 Topic Once daily 60 μ M 92% 12 ? ? ? ? ? ? ? ? [30 ] Tilapia piscidin 4 (TP4) Topic ? 2 mg/ml 27% 19 29% 19 ? ? ? ? ? ? [12 ] Tilapia piscidin 3 (TP3) Topic ? 2 mg/ml 23% 19 44% 19 ? ? ? ? ? ? [31 ] Proinsulin C S.c. Continuous 35 pmol/kg per minute ? ? ? ? 67% 10 ? ? ? ? [32 ] Camel milk peptide (CMP) Oral Once daily 25 mg/kg ? ? ? ? 37% 7 ? ? ? ? [33 ] Ghrelin S.c. Once daily 50 nmol/kg 17% 14 ? ? ? ? ? ? 0% 14 100 nmol/kg 0% 50% 200 nmol/kg 0% 67% [34 ] Epinecidin-1 (Epi-1) Topic Every three days 90 μ g/ml ? ? 65% 25 ? ? ? ? ? ? 900 μ g/ml 65% 9 mg/ml 71% [35 ] Marine collagen peptides (MCP) Topic Once daily ? 86% 21 ? ? ? ? ? ? ? ? [1 ] OM‒LV20 Topic Twice daily 0.5 nM ? 10 ? ? ? ? ? ? ? ? 1 nM ? 2.5 nM ? 5 nM ? 10 nM ? 20 nM 50% [13 ] Cathelicidin-OA1 Topic Twice daily 10 μ M 6% 10 ? ? ? ? ? ? ? ? 20 μ M 53% 40 μ M 66% [16 ] OA-GL21 Topic Twice daily 1 μ g/ml -3% 9 ? ? ? ? ? ? ? ? 10 μ g/ml 44% 100 μ g/ml 53% [36 ] Cathelicidin-NV Topic Twice daily 200 μ g/ml 91% 10 ? ? ? ? ? ? ? ? [37 ] Pollock Collagen Peptide (PCP) Oral ? 0.5 g/kg 27% 12 ? ? ? ? ? ? ? ? 2 g/kg 48% [38 ] OA-FF10 Topic Twice daily 1 μ M 52% 8 ? ? ? ? ? ? ? ? 10 μ M 52% 100 μ M 68% [39 ] Collagen peptides Oral Once daily 0.3 g/kg -27%/-92% 7 ? ? ? ? ? ? ? ? 0.6 g/kg -20%/-71% 0.9 g/kg 47%/-17% [40 ] OA-GL12 Topic Twice daily 0.1 nM 13% 10 ? ? ? ? ? ? ? ? 1 nM 44% 10 nM 63% [41 ] Ot-WHP Topic Once daily 200 μ g/ml 63% 8 ? ? ? ? ? ? ? ? [42 ] Active peptides (APs) Oral ? 0.5 g/kg 60% 14 ? ? ? ? ? ? ? ? 2 g/kg 80% [43 ] Skin collagen peptide Oral ? 2 g/kg 59%/45% 12 ? ? ? ? ? ? ? ? [44 ] Cathelicidin-DM I.v. Once daily 10 mg/kg ? ? ? ? ? ? ? ? ? ?
Results shown as a percentage of reduction in the average wound area of the groups treated with peptide compared to the control group on a given postinjury day. RF: reference; P: peptides; R: route; A: application; C: concentration; RWS: reduction in wound size; DA: day analyzed; PI: postinjury; ?: not reported or unclear; I.p.: intraperitoneal; S.c.: subcutaneous; I.v.: intravenously; CP1: collagen peptides bands at 10-15 kDa; CP2: collagen peptides <25 kDa; Ss-SCP:
Salmo salar skin collagen peptides; Tn-SCP:
Tilapia nilotica skin collagen peptides.
