Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 1

Review Article

Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds

Table 1

Main outcome in the treatment of skin wounds using peptides of animal origin.

InterventionMain outcome
Normal
wound
Infected
wound
Diabetic
wound
Ischemic
wound
Radiation +
wound
RFPRACRWS
(%)
DA
(PI)
RWS (%)DA
(PI)
RWS (%)DA
(PI)
RWS (%)DA
(PI)
RWS (%)DA
(PI)

[20]Thymosin β4TopicTwice5 μg/50μl62%7????????
I.p.Every two days60 μg/300μl61%
[21]TP508TopicSingle0.03 μg47%7????????
0.1 μg39%10
0.3 %g79%7
0.4 μg37%10
1 μg43%10
1 μg78%7
3 μg22%7
5 μg??
[22]TP508TopicSingle0.1 μg??????53%14??
[23]HB-107TopicThree times
per day
100 μg/ml63%11????????
[15]Marine collagen peptides (MCP)OralOnce daily2 g/kg76%16????????
[24]LL37TopicTwice daily10 μg??????????
[25]AH90TopicTwice daily250 μg/ml64%10????????
[26]Pardaxin (GE33)Topic?8 mg/ml58%2185%17??????
[27]TylotoinTopicTwice daily20 μg/ml89%10????????
[28]CW49TopicTwice daily200 μg/ml64%8??23%8????
[29]E1TopicOnce daily60 μM92%12????????
[30]Tilapia piscidin 4 (TP4)Topic?2 mg/ml27%1929%19??????
[12]Tilapia piscidin 3 (TP3)Topic?2 mg/ml23%1944%19??????
[31]Proinsulin CS.c.Continuous35 pmol/kg per minute????67%10????
[32]Camel milk peptide (CMP)OralOnce daily25 mg/kg????37%7????
[33]GhrelinS.c.Once daily50 nmol/kg17%14??????0%14
100 nmol/kg0%50%
200 nmol/kg0%67%
[34]Epinecidin-1 (Epi-1)TopicEvery three days90 μg/ml??65%25??????
900 μg/ml65%
9 mg/ml71%
[35]Marine collagen peptides (MCP)TopicOnce daily?86%21????????
[1]OM‒LV20TopicTwice daily0.5 nM?10????????
1 nM?
2.5 nM?
5 nM?
10 nM?
20 nM50%
[13]Cathelicidin-OA1TopicTwice daily10 μM6%10????????
20 μM53%
40 μM66%
[16]OA-GL21TopicTwice daily1 μg/ml-3%9????????
10 μg/ml44%
100 μg/ml53%
[36]Cathelicidin-NVTopicTwice daily200 μg/ml91%10????????
[37]Pollock Collagen Peptide (PCP)Oral?0.5 g/kg27%12????????
2 g/kg48%
[38]OA-FF10TopicTwice daily1 μM52%8????????
10 μM52%
100 μM68%
[39]Collagen peptides
(CP1/CP2)
OralOnce daily0.3 g/kg-27%/-92%7????????
0.6 g/kg-20%/-71%
0.9 g/kg47%/-17%
[40]OA-GL12TopicTwice daily0.1 nM13%10????????
1 nM44%
10 nM63%
[41]Ot-WHPTopicOnce daily200 μg/ml63%8????????
[42]Active peptides (APs)Oral?0.5 g/kg60%14????????
2 g/kg80%
[43]Skin collagen peptide
(Ss-SCP/
Tn-SCP)
Oral?2 g/kg59%/45%12????????
[44]Cathelicidin-DMI.v.Once daily10 mg/kg??????????

Results shown as a percentage of reduction in the average wound area of the groups treated with peptide compared to the control group on a given postinjury day. RF: reference; P: peptides; R: route; A: application; C: concentration; RWS: reduction in wound size; DA: day analyzed; PI: postinjury; ?: not reported or unclear; I.p.: intraperitoneal; S.c.: subcutaneous; I.v.: intravenously; CP1: collagen peptides bands at 10-15 kDa; CP2: collagen peptides <25 kDa; Ss-SCP: Salmo salar skin collagen peptides; Tn-SCP: Tilapia nilotica skin collagen peptides.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.