Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma

Figure 2

Analysis of airway obstruction in HDM-induced experimental asthma. (a) The asthmatic mouse model with lentiviral vector of shRNA or vehicle pretreatments (10⁷ U per mouse) intranasally (i.n.) 48 h before HDM challenge; further experiments were conducted 18-20 hrs after the last HDM exposure. (b–d) AHR (b), airway resistance under high concentration of acetylcholine (Ach) (c), and baseline compliance (Cdyn) (d) in response to Ach measured in saline-challenged, HDM-challenged, vehicle-pretreated HDM-challenged, and shRNA-pretreated HDM-challenged mice. (b) and : control group compared with HDM-challenged group; , : vehicle-pretreated HDM-challenged group compared with shRNA-pretreated HDM-challenged group. (c, d) and . ns: not significant.

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