Research Article
Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma
Figure 3
Impact of Nur77 on chronic inflammation and airway remodeling in HDM-induced asthma model. (a) BALF cell counts and their differentiation were determined using a haemocytometer in at least 200 cells. (b) The differential expression profiles of the 10 cytokines. (c, d) BALF were collected for detecting Ig-E (c) and IL-17a (d) production. (e) Lung sections were stained with H&E to evaluate leukocyte infiltration; scale bar: 200 μm (inset: 50 μm). (f) Lung sections were stained with PAS to analyze goblet cell hyperplasia; scale bar: 50 μm. (g) Quantitative analysis of mucus production in lung sections. (h) Lung sections were stained with Masson’s trichrome to assess the collagen deposition and fibrosis; scale bar: 50 μm. , , and . ns: not significant.
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