Safflor Yellow B Attenuates Ischemic Brain Injury via Downregulation of Long Noncoding AK046177 and Inhibition of MicroRNA-134 Expression in Rats

Figure 4

Effect of safflor yellow B on antioxidant enzyme activity and MDA level. Rats and primary fetal cortical cells were used to establish the I/R model and the OGD/R model, respectively. After I/R for 24 h, the cerebral cortex and cells from different groups were collected. The activities of SOD and GSH-Px and the MDA levels in tissues and cells were determined with the spectrophotometrical method according to the procedure described by the assay kit. (a1), (b1), and (c1) represent the activities of SOD and GSH-Px and the MDA level in cerebral cortex tissue. (a2), (b2), and (c2) represent the activities of SOD and GSH-Px and the MDA level in cells. Data are presented as ( in brain tissues, or in cells). One-way ANOVA test was used to determine statistical significance. vs. the sham group or the control group, ^# or ^##vs. the I/R group or the OGD/R group, ^Δ or ^ΔΔvs. the AK046177 siRNA group, and ⁺ or ⁺⁺vs. the SYB group.

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