Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery

<div>Anesthesia and surgery elevate tau acetylation and decrease the neuronal SIRT1 expression in the hippocampus of aged rats. (a)–(d) Representative immunoblot bands and the corresponding densitometry analysis of ac-tau (k280), ac-tau (k686), SIRT1 expression normalized to <i>β</i>-actin, and p-tau (AT8) normalized to total tau. (e) Immunostaining of SIRT1 (red) and NeuN (green) in the control and sevoflurane+surgery groups. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery 