Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery

<div>Resveratrol pretreatment increases the neuronal SIRT1 expression in the hippocampus of aged rats exposed to anesthesia and surgery. (a) Immunostaining of SIRT1 (red) and NeuN (green). (b)–(d) Quantification of SIRT1-positive and NeuN-positive cells. (e) Representative immunoblot band and the corresponding densitometry analysis of the SIRT1 expression normalized to <i>β</i>-actin. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery 