Overexpression of miR-506-3p Aggravates DBP-Induced Testicular Oxidative Stress in Rats by Downregulating ANXA5 via Nrf2/HO-1 Signaling Pathway

Figure 1

miR-506-3p was highly expressed in DBP-induced oxidative stress injury in rats: (a) body weight of these rats treated with the DBP group and the normal group; (b) the AGD in these rats treated with the DBP group and the normal group; (c) the ratio of AGD/rat weight in these rats treated with the DBP group and the normal group; (d) images of gross morphology of the testes and testicular weight in these rats treated with the DBP group and the normal group; (e) the ratio of testicular weight/rat weight in these two groups; (f) H&E staining of testis tissues in DBP-treated rats and normal rats (×400); (g) hierarchical clustering analysis of the differentially expressed miRNAs of testis samples in these rats treated with the DBP group and the normal group; (h) miR-506-3p expression level in these rats treated with the DBP group and the normal group using RT-qPCR; (i) miR-506-3p expression level in testis tissues of DBP-treated rats following miR-506-3p agomir and NC agomir injection detected using RT-qPCR. The data are showed as . Significantly different from the normal group. , ; ns indicated no significance.

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