Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

Figure 3

The comparison of Nrf2 activation in CCVD. (a) Nrf2 activation can protect VECs, inhibit the proliferation and migration of VSMCs, and suppress foam cell formation. OxLDL: oxidized low density lipoprotein. (b) In CI, Nrf2 activation can inhibit the activation of microglia and promote its polarization to the M2 phenotype, activate microglia uptake heme and protect neurons, and protect neurons. In MI, Nrf2 activation can promote proinflammatory M1 macrophage polarization to the M2 phenotype, enhance phagocytosis of macrophages, and protect cardiomyocytes.

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