Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats

Figure 8

Proposed pathway for Eze and its downstream targets. Eze increases levels of phosphorylated AMPK and activates Nrf2, which translocates into the nucleus to increase the transcription of HO-1—a protein that inhibits ROS and inflammation.