Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats

Table 1

Summary of experimental groups and mortality rate in the study. A total of 198 rats were used in the following groups: naive (24), sham (24), and MCAO (150). Each experiment utilized a predefined exclusion criterion: no infarction volume after MCAO ().

Groups	Neuroscore; TTC staining	IHC; DHE	MDA	WB	Mortality	Exclusion	Subtotal
Experiment 1
Sham				6	0	0	6
MCAO (6 h, 12 h, 24 h, and 72 h)					10 (17.2%)	3	61
Experiment 2
Sham	6	6	6	6	0	0	18
MCAO+vehicle	6	6	6	6	5 (21.7%)	1	24
MCAO+Eze (250 μg/kg)	6				1 (14.3%)	0	7
MCAO+Eze (500 μg/kg)	6	6	6	6	3 (14.3%)	0	21
MCAO+Eze (1 mg/kg)	6				1 (14.3%)	1	8
Experiment 3
Naive+DMSO				6	0	0	6
Naive+dorsomorphin				6	0	0	6
Naive+Eze+DMSO				6	0	0	6
Naive+Eze+dorsomorphin				6	0	0	6
MCAO+Eze+DMSO	6			6	1 (14.3%)	0	7
MCAO+Eze+dorsomorphin	6			6	2 (25%)	0	8
MCAO+Eze+Scr siRNA	6			6	0	0	6
MCAO+Eze+Nrf2 siRNA	6			6	1 (14.3%)	1	8
Total	54	18	18	78 (+42)	24 (16.7%)	6	198