Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway

<div>BAI ameliorated learning and memory deficits in LPS-induced mice. Mice were divided into four groups: control, LPS, BAI+LPS, and BAI. (a) Chemical molecular formula of BAI. (b) Schematic timeline of the experimental procedure. (c) The escape latency of LPS-induced mice in the MWM navigation test. (d) Analysis of the time spent in each quadrant during the probe trial of the MWM. (e) The platform crossing times during the probe trial of the MWM test. 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BAI, baicalin; MWM, Morris water maze; LPS, lipopolysaccharide; SEM, standard error of the mean.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway 