Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway

Figure 6

BAI suppressed the HMGB1 pathway by elevating SIRT1 in the hippocampus of LPS-induced mice. (a) HMGB1 immunofluorescence (green) in microglial cells (Iba-1+; red) counterstained with DAPI (blue), following LPS and BAI treatment; . Arrows point to HMGB1-positive microglial cells (Iba-1+). (b) Western blot analysis confirming the effect of BAI and EX-527 on SIRT1 and HMGB1 protein expression in LPS-induced mice. Data are expressed as the (). , , control vs. LPS or LPS+EX-527; ^##, ^###, BAI+LPS vs. LPS; ^&, ^&&, BAI+LPS vs. BAI+LPS+EX-527.

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