Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer’s Disease

Figure 9

Effects of SF on the cytotoxicity and NO production in the LPS-stimulated BV-2 cells. (a) Cell viability of BV-2 cells treated with SF (0.5, 1, 2, 4, 8, 16, and 32 μM) for 24 h. (b) The cell viability of BV-2 cells pretreated with SF (1 and 2 μM) for 1 h followed by treatment with LPS (2 μg/mL) for another 23 h. (c) The NO production of BV-2 cells pretreated with SF (1 and 2 μM) for 1 h followed by treatment with LPS (1 μg/mL) for another 23 h. Cell viability was assessed using the MTT assay. NO production was assessed using Griess reagent. The results are expressed as the (). as compared with the control group; ^## as compared with the LPS-treated control group.

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