PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease

<div>Cytoskeletal disruption of intestinal mucosa in celiac disease (CD) and of duodenal epithelial cells. Actin filament structure was investigated by phalloidin (orange) staining in duodenal mucosa of children with CD and controls (a) and in FHs74Int duodenal epithelial cells (b) after treatment with H<sub>2</sub>O<sub>2</sub> (1000 <i>μ</i>M) in the absence or presence of Comp23 (0.001 <i>μ</i>M). Cell nuclei were counterstained with DAPI (blue). White arrows indicate burst cells. Scale bar: 500 <i>μ</i>m, 100 <i>μ</i>m, and 50 <i>μ</i>m. The percent of intact and damaged cells (c) was determined by graphical analysis. Results are presented as the percentage of total cells in a field of view (<svg height="8.55521pt" id="M90" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 63.7991 8.55521" width="63.7991pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,21.421,0)"><path d="M456 178V225H360V632H320C217 496 115 347 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease 