PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease

Figure 7

Schematic model of the proposed mechanism underlying the protective effect of PARK7 against oxidative damage of duodenal epithelial cells in celiac disease. Our results showed that treatment with Comp23, a PARK7-binding compound under oxidative stress conditions, results in enhanced transcriptional activity, inducing expression of stress-response elements, such as antioxidant or cell-cycle regulators. This effect of PARK7 leads to reduced cellular damage and improved cell adhesion, contributing to the maintenance of integrity in the inflamed mucosa. Comp23: PARK7-binding compound; ROS: reactive oxygen species; CAM: cell adhesion molecule.