The HIPPO Transducer YAP and Its Targets CTGF and Cyr61 Drive a Paracrine Signalling in Cold Atmospheric Plasma-Mediated Wound Healing

Figure 3

mRNA expression of HIPPO signalling effectors after CAP treatment: mRNA expression of YAP, CTGF, and Cyr61 in HaCaTs (a) and GM Fbs (b) measured 3, 6, 18, and 24 hr after CAP treatment by qPCR and normalized to relative gene expression (ΔΔCT values on a log2 scale). The -axis represents CAP treatment time and incubation time after plasma treatment. Data are represented as of either three (a) or four (b) independent experiments. Statistical analysis was performed using unpaired -test with Welch’s correction for multiple comparisons, along with normalization to the untreated control.

(a)

(b)