The HIPPO Transducer YAP and Its Targets CTGF and Cyr61 Drive a Paracrine Signalling in Cold Atmospheric Plasma-Mediated Wound Healing

Figure 8

Schematic of keratinocyte activation by CAP modulated fibroblasts: the primary event in this scheme is the generation of reactive species in response to CAP treatment. These reactive species function as secondary messengers and stimulate the production of HIPPO signalling effectors such as CTGF in HaCaT and CTGF and Cyr61 by dermal fibroblasts in the vicinity. These extracellular matrix proteins that are released from fibroblasts in turn activate keratinocytes, accelerate migration, and promote wound healing.