The Activation of Phosphatidylserine/CD36/TGF-β1 Pathway prior to Surgical Brain Injury Attenuates Neuroinflammation in Rats

Figure 3

PS liposome pretreatment effects on brain edema and neurological outcomes at 24 h and 72 h post-SBI. PS liposome pretreatment significantly reduced the brain edema at 24 h post-SBI (a). PS 0.5 mg pretreatment improved Garcia scores (c), but not beam balance scores (e). The neuroprotection of PS 0.5 mg pretreatment on brain edema and Garcia scores persisted at 72 h post-SBI (b, d). PS pretreatment did not improve beam balance scores (e, f). vs. sham; ^&&, ^& vs. SBI+vehicle, ^# vs. SBI+PS 0.5 mg. RF: right frontal lobe; LF: left frontal lobe; RP: right parietal lobe; LP: left parietal lobe; C: cerebellum; BS: brain stem.

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