Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Figure 1

Photomicrographs of kidney sections stained with hematoxylin and eosin. (a, b) Control and G. lucidum groups show normal histology of glomeruli (G) and tubules (T). (c, d) The cisplatin group shows congested glomeruli and renal tubules (black arrow), severe tubular dilation, perivascular lymphocytic cell infiltration (G), and tubular cast formation (arrowheads). (e) The CDDP+GL daily group shows restored histological picture of the kidney. (f) The CDDP+GL EOD group shows mild vacuolar degeneration in epithelial lining renal tubules (short black arrows). (g) The CDDP+GL inject. group shows edematous swelling of Bowman’s capsule of glomeruli (G), tubular dilation (long black arrows) with vacuolar degeneration in epithelial lining renal tubules (short black arrows) (T). X: 400 bar 50. (h) Statistical analysis of tubular injury scores; values are (). ^X compared to the control group, ^y compared to the CDDP group, ^z compared to the CDDP+GL daily, ^$ compared to the CDDP+GL EOD group, and ^# compared to the CDDP+GL inject. group using one-way ANOVA followed by Tukey-Kramer as post hoc test. CDDP: cisplatin; GL: Ganoderma lucidum; EOD: every other day.

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