Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Table 1

Effects of cisplatin and Ganoderma lucidum on nephrotoxicity indices, oxidative stress, and inflammatory markers in kidney tissues of rats.

	BUN (mg/dl)	Serum creatinine (mg/dl)	SOD (ng/mg protein)	H2O2 (ng/mg protein)	HMGB-1 (pg/mg protein)
Control	^y,z,$,#	^y,$,#	^y	^y	^y,z,$,#
GL alone	^y,z,$,#	^y,$,#	^y	^y	^y,$,#
CDDP	^z,$,#	^z,$,#	^z,$,#	^z,$,#	^z,$
CDDP+GL daily	^$,#	^$,#			^$,#
CDDP+GL EOD
CDDP+GL inject.

Values are (). ^X compared to the control group, ^y compared to the CDDP group, ^z compared to the CDDP+GL daily group, ^$ compared to the CDDP+GL EOD group, and ^# compared to the CDDP+GL inject. group using one-way ANOVA followed by Tukey-Kramer as post hoc test. CDDP: cisplatin; GL: Ganoderma lucidum; EOD: every other day; BUN: blood urea nitrogen; SOD: superoxide dismutase; H₂O₂; hydrogen peroxide; HMGB-1: high-mobility group box-1.