Research Article

Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway

Figure 1

Effects of I/R injury and DZ treatment on the expression of miRNAs in rat myocardial tissue. (a) The schematic diagram of the established myocardial I/R injury rat model. (b, c) Representative images of hearts from the NC, I/R, and DZ rats, hearts were stained with TTC to reveal infarcted tissue, the red area represents the viable myocardium, and the white area represents ischemic dead tissue. . (d) Rat myocardial tissues in different groups were detected by HE staining. . (e) RNA sequencing detects the miRNA expression difference in normal and I/R injury myocardial tissues. (f) miRNA screening: miRNA expression in the myocardium was assessed by qRT-PCR. Data were expressed as (). #, ##, and ###, compared to the normal group; , , and , compared to the I/R group.