Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase

Figure 1

The changes in serum catalase activity and H₂O₂ levels in a Chinese familial AD pedigree with E22K mutation. (a) E22K mutation in a Chinese early-onset familial Alzheimer’s disease pedigree. (b) APP693 mutation identified by gene sequencing. (c) Human serum H₂O₂ levels detected by an H₂O₂ kit (Con group: ; AD group: , ). Con: control; E22K: patients with E22K mutant; AD: pure AD patients. (d) Human serum catalase activity analyzed by a catalase kit (). (e, f) Changes in human serum catalase activity and H₂O₂ levels after E22K and Aβ incubation 0, 1, and 2 h (, vs. control, respectively).

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