Carbon Monoxide Being Hydrogen Sulfide and Nitric Oxide Molecular Sibling, as Endogenous and Exogenous Modulator of Oxidative Stress and Antioxidative Mechanisms in the Digestive System

Table 4

Antioxidative effects of CO donors in various in vitro and in vivo experimental models of pancreatic injury.

Experimental model (publication)	CO donor	Dose	Form of application
Retrograde infusion of sodium taurocholate-induced severe acute pancreatitis rat model [103]	CORM-2	8 mg/kg	Intravenous injection
↓ NF-κB activity
Retrograde injection of sodium taurocholate-induced acute necrotizing pancreatitis rat model [104]	MC	500 mg/kg	Orally
↓ NF-κB activity
Choline-deficient ethionine-supplemented diet-induced acute pancreatitis mouse model [105]	CO-HbV	1,000 mg Hb/kg	Via tail vein
↓ Oxidative stress