Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease

Figure 1

Schematic presentation of the human APOE genotype and APOE polymorphisms. The human APOE gene is situated in the long arm of chromosome 19. In exon 4 of chromosome 19, two nonsynonymous single nucleotide polymorphisms (SNPs) including rs429358 and rs7412 produce 3 main allelic variants (E2, E3, and E4). The resulting APOE2, APOE3, and APOE4 isoforms vary from one another at amino acid residues 112 or 158.