Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease

Figure 3

Increasing lipidation of the astrocytic pool of APOE. APOE is principally produced by astrocytes in the brain. Activation of nuclear hormone receptors including LXR and RXR plays an essential role in the expression of APOE and ABCA1. Moreover, ABCA1 is very important for the lipidation of APOE and increasing the expression of ABCA1 contributes to enhanced lipidation of all APOE polymorphisms (indicated by red arrows). It is assumed that enhanced lipidation of APOE will be valuable for several AD-relevant endpoints.