Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease

Figure 4

Editing of APOE4 by CRISPR to generate an APOE3-like structure. The APOE4 allele is generally produced by APOE chromosome 19 (19q13.2). The coding of DNA for APOE4 varies from APOE3, which is considered as the benign gene for AD, by only 1 nucleotide (explicitly, the 112th position is cysteine in APOE3 and arginine in the case of APOE4). Particularly, the CRISPR method could be used for converting the APOE4 gene into APOE3.