Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 3

Research Article

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

Figure 3

pSTAT3 and the downstream protein, SLC7A11, were significantly increased in IIR-ALI and regulated by Nrf2. (a) The level of STAT3 mRNA in the Nrf2-/- mice compared with WT. , , , #, and ## between the groups. Compared with the sham group; #Nrf2-/-compared with that of the WT group ( per group). (b) WT and Nrf2-/- mice were divided into four groups: sham, IIR, IIR+Fe, and IIR+Fer-1. The level of STAT3, pSTAT3, and SLC7A11protein expression was measured using a western blot. (c) The representative quantification of pSTAT3 protein, normalized to the corresponding level of total STAT3 ( per group). (d) The representative quantification of SLC7A11 protein, normalized to the corresponding level of β-actin ( per group). , , #, and ## between the groups. Compared with the sham group; #Nrf2-/-compared with that of the WT group.
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