Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 4

Research Article

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

Figure 4

Ferroptosis occurs in OGD/R-induced lung epithelial cell damage. (a) Cell survival after oxygen-glucose deprivation (OGD) 8 h and reoxygenation (R) 12 h performed by a CCK8 assay. Cells were divided into four groups: (1) control, (2) OGD/R, (3) OGD/R+Fe (800 μg/mL), and (4) OGD/R+Fer-1 (0.1 μM). (b) The level of cellular GSH after OGD/R was evaluated with a GSH assay. (c) The level of cellular MDA after OGD/R was evaluated with an MDA assay. (d) The level of GPX4 and Nrf2 protein expression was measured with a Western blot. , , , #, and ## between the groups. Compared with the control group. #Compared with the OGD/R group.

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