Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons

Figure 7

Possible mechanism of action of glutamate on IGF signaling. Glutamate stimulates the activation of NMDARs, leading to the activation of NR2B subunits and the release of calcium ions. The overloaded calcium ions act on the IGF-1R. We used a variety of highly selective inhibitors and siRNA technology for key research targets to verify the conclusions of this study.