Integrated Metabolomic and Lipidomic Analysis Reveals the Neuroprotective Mechanisms of Bushen Tiansui Formula in an Aβ1-42-Induced Rat Model of Alzheimer’s Disease

Table 3

Metabolite pathway changes between sham and AD groups.

No.	Pathway	Hits	Total			FDR	Impact
1	Sphingolipid metabolism	3	21	0.0011		0.0901	0.46248
2	Glycerophospholipid metabolism	3	36	0.0052	5.2518	0.21999	0.21631
3	Linoleic acid metabolism	1	5	0.0506	2.9834	1	0
4	Alpha-linolenic acid metabolism	1	13	0.1266	2.0663	1	0
5	Glycosylphosphatidylinositol (GPI) anchor biosynthesis	1	14	0.1357	1.997	1	0.00399
6	Cysteine and methionine metabolism	1	33	0.2925	1.2293	1	0.05271
7	Arachidonic acid metabolism	1	36	0.3147	1.1562	1	0
8	Arginine and proline metabolism	1	38	0.3291	1.1115	1	0
9	Purine metabolism	1	65	0.4979	0.69746	1	0.02939

Hits represent the matched number of metabolites in one pathway. represents the original value calculated from the enrichment analysis. FDR represents the value adjusted using the false discovery rate.