Integrated Metabolomic and Lipidomic Analysis Reveals the Neuroprotective Mechanisms of Bushen Tiansui Formula in an Aβ1-42-Induced Rat Model of Alzheimer’s Disease

Table 4

Metabolite pathway changes between BSTSF and AD groups.

No.	Pathway	Hits	Total			FDR	Impact
1	Alanine, aspartate, and glutamate metabolism	2	28	0.0156	4.157	1	0.3101
2	D-Glutamine and D-glutamate metabolism	1	6	0.0419	3.1725	1	0
3	Arginine biosynthesis	1	14	0.0953	2.3509	1	0
4	Glycosylphosphatidylinositol (GPI) anchor biosynthesis	1	14	0.0953	2.3509	1	0.00399
5	Nicotinate and nicotinamide metabolism	1	15	0.1017	2.2851	1	0
6	Histidine metabolism	1	16	0.1082	2.2238	1	0
7	Pantothenate and CoA biosynthesis	1	19	0.1273	2.0615	1	0
8	Beta-alanine metabolism	1	21	0.1398	1.9678	1	0
9	Cysteine and methionine metabolism	1	33	0.2114	1.554	1	0.02089
10	Glycerophospholipid metabolism	1	36	0.2284	1.4765	1	0.10449
11	Aminoacyl-tRNA biosynthesis	1	48	0.2933	1.2265	1	0

Notes: hits represent the matched number of metabolites in one pathway. represents the original value calculated from the enrichment analysis. FDR represents the value adjusted using the false discovery rate.