Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

<div>Accumulation of p62 by trehalose was not due to impaired proteasome degradation. (a, b) Time-dependent increase in p62 protein level by MG132 in cell lysate using immunoblot. (c) Proteasome activity level in whole-cell lysates from cells. (d) Trehalose increased p62 level in the presence of MG132. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells 

Figure 3 | Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells 