Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells
Accumulation of p62 by trehalose was not due to impaired proteasome degradation. (a, b) Time-dependent increase in p62 protein level by MG132 in cell lysate using immunoblot. (c) Proteasome activity level in whole-cell lysates from cells. (d) Trehalose increased p62 level in the presence of MG132. Data represent the of 3 independent experiments. Statistical analysis was performed by one-way ANOVA followed by multiple comparison tests. , vs. control.
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