Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 6

Research Article

Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

Figure 6

Changes in the mRNA and/or protein levels in the autophagy-lysosomal pathway and oxidative stress. (a, b) Immunoblot showing an increase in the expression of TFEB in whole-cell lysate by trehalose. (c, d) RT-qPCR showing transcriptional changes in autophagy genes ATG5 and ATG7 and oxidative stress pathway targets, including NRF2, HSP 27, and VEGF-A. Data represent the of 3 independent experiments. Statistical analysis was performed using either unpaired test or one-way ANOVA test, followed by Dunnett’s post hoc test; , , .
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