Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

<div>Cytoprotection of trehalose against oxidative damage by hydroquinone (HQ) in ARPE-19 cells. (a) Trypan blue assay reveals that trehalose is nontoxic over a wide dose range. (b) Trehalose decreased basal level of reactive oxygen species (ROS) assessed using CM-H<sub>2</sub>DCFDA assay (c, d) Trehalose pretreatment improves the viability of cells and lowered the protein carbonyl levels in cells exposed to HQ. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells 

Figure 7 | Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells 