Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

<div>Autophagy upregulation by trehalose protects against hydroquinone- (HQ-) induced oxidative stress in human RPE-19 cells. (a–d) Immunoblots for changes in protein expression of LC3-II, p62, and Nrf2 in cells preincubated with trehalose or vehicle before HQ exposure. (e) Trypan blue assay showing loss of protection against HQ in shRNA ATG5 cells pretreated with trehalose. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells 

Figure 8 | Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells 