Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet

Figure 4

CL pathway gene expression and CL levels in young and aged mouse skeletal muscle. Calf muscle tissues were collected over a circadian cycle from young (2-3 months) and aged (20-22 months) mice. (a) qPCR analysis of core clock gene expression over the circadian cycle (). (b) qPCR analysis of CL pathway gene expression over the circadian cycle (). (c) CL levels over the circadian cycle were measured by fluorometric assays (). Data are presented as . , , one-way ANOVA with Dunnett’s multiple comparisons test or ^##, student’s -test.

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