Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway

<div>ROS removal by NAC abolished the protective effect of TSA against AP induced by caerulein<i>.</i> (a) Representative HE staining of pancreatic tissues in magnifications 100x and 400x. (b) Histopathological scores of pancreatic tissues. (c) Serum amylase and lipase levels. (d, e) Protein levels of Nrf2 and total HO-1 in pancreatic tissues were analyzed by western blotting. 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V represents vehicle; S represents saline; M represents medium-dose TSA (25 mg/kg); N represents ROS inhibitor NAC.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway 