Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Figure 2

Liver weight and liver cholesterol content. (a) Liver weight at the end of the experiment of wild-type mice supplemented with atherogenic diet constituents. (b) Liver-to-body weight ratio of wild-type mice. (c) Hepatic cholesterol content of wild-type mice. (d) Hepatic lipid percentage of wild-type mice. All values are expressed as (). (e) Liver weight at sacrifice of Mdr2-/- mice supplemented or not with cholesterol. (f) Liver-to-body weight ratio of Mdr2-/- mice. (g) Hepatic cholesterol content of Mdr2-/- mice. All values are expressed as (). Means with different letters are statistically different, .

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