Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Figure 8

Nrf-2-mediated antioxidative response. (a) Nrf-2 nuclear protein levels and Nrf-2 downstream activity in wild-type mice supplemented with atherogenic diet constituents represented by HO-1 relative mRNA levels (Figure 7), GST-1α relative mRNA levels, GCLC relative mRNA levels, NQO-1 relative mRNA levels, and CCNA2 (cyclin A2) relative mRNA levels. All values are expressed as (). (b) Nrf-2 nuclear protein levels and Nrf-2 downstream activity in Mdr2-/- mice treated or not with cholesterol. Nrf-2 activity is represented by HO-1 relative mRNA levels (Figure 7), GST-1α relative mRNA levels, GCLC relative mRNA levels, NQO-1 relative mRNA levels, and CCNA2 (cyclin A2) relative mRNA levels. All values are expressed as (). Means with different letters are statistically different, .

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