Cellular Mechanisms Triggered by the Cotreatment of Resveratrol and Doxorubicin in Breast Cancer: A Translational In Vitro–In Silico Model

Figure 5

A network core composed of 24 hub-bottleneck (H-B) nodes is common between the MCF7 CP-PPI network, breast cancer CP-PPI network, and intersection CP-PPI network. (a) Centrality analysis of the intersection CP-PPI network. Dashed lines represent the thresholds calculated for each centrality, degree, and betweenness. Proteins/genes are represented by black dots, while compounds are marked in blue (Rsv) and red (Doxo). (b) H-B intersection network: all H-B nodes from the intersection CP-PPI network were selected to compose this graph. Nodes highlighted in red and blue are modulated by Doxo and Rsv, respectively; yellow nodes represent genes modulated by both compounds. Network connectivity of Rsv and Doxo nodes is also highlighted in blue and red, respectively. (c) Venn diagram between the H-B MCF7 CPPI network, H-B Breast CP-PPI network, and intersection CP-PPI network. (d) Venn diagram between the H-B MCF7 CP-PPI network, H-B Breast CP-PPI network, and H-B intersection CP-PPI network. (e) H-B CP-PPI network: network composed of 24 H-B nodes common between all H-B CP-PPI networks explored. H-B: hub-bottleneck; NH-B: non-hub-bottleneck; H-NB: hub-nonbottleneck. Color legends are similar to (b).

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