Research Article
Effects of Early MSC Intervention on Preventing the Streptozotocin-Induced T1DM Progression in Mice
Figure 3
MSC infusion inhibits Th1 polarization. On the 56th day of the experiment, spleen lymphocytes were harvested, and the Th1 subset ratio was detected by fluorescence-activated cell sorting (FACS) analysis. Gated on CD3 and CD4, the frequencies of Th1 cells of the NC, DM, and MP groups are shown in (a–c), and statistics is shown in (d). (e) and (f) exhibit the quantitative real-time PCR detecting the expression of IFN-γ and TNF-α. (e) and (f) show the serum concentration of IFN-γ and TNF-α.
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