Dexmedetomidine Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting p75NTR-Mediated Oxidative Stress and Apoptosis

Figure 1

DEX improves survival rate and attenuates kidney damage induced by LPS. (a) Survival rates of septic mice, 10, 30, and 50 μg/kg DEX pretreatment groups (, versus control; ^# versus LPS, per group; log-rank (Mantel-Cox) test). (b, c) Cr and BUN levels in serum. (d) Histopathological changes in kidney tissues (); yellow arrow indicates tubular necrosis and vacuolar degeneration. (e) Tubular injury score (, , and versus control; ^## versus LPS. Data were presented as , ). H&E: hematoxylin and eosin; PAS: Periodic Acid-Schiff stain.

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