A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16

Figure 1

Naringin extended adult lifespan in C. elegans. (a) Chemical structure of naringin. (b) Survival curves of wild-type (N2) animals raised at 20°C on NGM plates containing 50, 100, 200, and 500 μM of naringin or control plates without naringin. (c) Dose-response analysis of naringin. Wild-type (N2) animals were treated with 25, 50, 100, and 200 μM of naringin at least two independent experiments, plotting the mean changes of lifespan. Error bars represent the standard deviation (SD). (d) Effects of naringin on the lifespan of wild-type (N2) animals raised at 20°C on NGM plates in the absence (0 μM) or presence (50 μM) of naringin with two different feeding procedures including live bacteria (E. coli OP50) and dead OP50 (65°C 30 min).

(a)

(b)

(c)

(d)