A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16

Figure 6

Naringin does not act on germline signaling. (a) The offspring of each animal was counted daily at each concentration, and total reproduction outputs were determined by each group. The error bar represent the standard deviation (SD), and no value reached the significance limit of by independent -test. Statistical details and repeats of these experiments are summarized in Table S11 (Supplementary information). (b) Survival curves of glp-1 mutants in the control or treated with 50 μM naringin; naringin could further extend the mean lifespan relative to control plates without naringin. Statistical details and repeats of these experiments are summarized in Table S1 (Supplementary information).

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