EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells

<div>Changes in DNMT1 and DNMT3a binding at the Klotho promoter in HK-2 cells. Relative ChIP enrichment was quantified by qPCR. IgG (immunoglobulin G) was used as the negative control. NG: normal glucose (5.5 mM); HG: high glucose (60 mM); EGCG: HK-2 cells treated with 1 <i>μ</i>M EGCG. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells 