EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells

<div>The protein expression of TGF-<i>β</i>1 and <i>α</i>-SMA in HK-2 cells detected by western blotting. (a) The protein expression of TGF-<i>β</i>1 and <i>α</i>-SMA in HK-2 cells of each group. The expression of TGF-<i>β</i>1/GAPDH (b) and <i>α</i>-SMA/GAPDH (c) was quantitatively analyzed in each group. NG: normal glucose (5.5 mM); HG: high glucose (60 mM); EGCG: HK-2 cells treated with 1 <i>μ</i>M EGCG; Klotho KO: Klotho gene knockout; Klotho OE: Klotho gene overexpression. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells 