The Role of BRG1 in Antioxidant and Redox Signaling

Figure 3

The figure shows the transcriptional activation of BRG1 on a variety of ARS-related genes, including NOX (1,2,4), eNOS, CAV1, and autophagy-related genes. Interestingly, BRG1 not only restores the expression of eNOS to resist oxidative stress but also aggravates oxidative stress by activating CAV1 to limit eNOS activity and NO bioavailability. CAV1: caveolin-1; eNOS: endothelial nitric oxide synthase; NOX: NADPH oxidase complex.